The Flask of Wondrous Physick is a special item in Elden Ring. Compared to your Flask of Crimson Tears and Flask of Cerulean Tears (i.e., HP potions and mana potions respectively), this one allows you to combine different effects to make the ideal concoction. Here’s our Elden Ring guide to help you with the Flask of Wondrous Physick and the Tears that you can find.

Elden Ring guide – Flask of Wondrous Physick and Crystal Tears locations

The Flask of Wondrous Physick in Elden Ring can be found in the Third Church of Marika. This location is in Mistwood, a small area along the borders of Limgrave and Caelid. You can pick up an additional Sacred Tear for your regular flasks, and it’s where Melina pays you a visit as well.

With the Flask of Wondrous Physick in your possession, you’ll notice another command once you interact with a Site of Grace. This lets you make different combinations of Tears (at least two) so that you can gain both effects. Just remember that the Flask of Wondrous Physick only has a single use, and you have to rest in a Site of Grace to replenish it.

Elden Ring Tear locations for the Flask of Wondrous Physick

Most of the Tears used by the Flask of Wondrous Physick in Elden Ring will come from Minor Erdtrees in various regions. Simply find that region’s map and head to the Erdtree icon to reach it. Oftentimes, these locations will be guarded by bosses that you need to defeat to acquire the Tears as loot. As for the rest, they might still be found in certain Minor Erdtrees, albeit undefended, or in other locations.

Note: You can take a look at our guides regarding the Erdtree Avatar/Putrid Avatar, Ulcerated Tree Spirit, and Wormface if you need help with those bosses.

Mistwood: Third Church of Marika – Near where you get the flask.

• Crimson Crystal Tear – Restores half of your total HP.

Mistwood: Minor Erdtree – Unguarded

• Spiked Cracked Tear – Enhances charged attacks temporarily.
• Greenspill Crystal Tear – Temporarily boosts stamina.

Weeping Peninsula: Minor Erdtree – Erdtree Avatar

• Opaline Bubble Tear – Damage negation.
• Crimsonburst Crystal Tear – Steadily restores HP.

Liurnia of the Lakes: Minor Erdtree (Southwest) – Erdtree Avatar

• Cerulean Crystal Tear – Restores half of your total FP.
• Ruptured Crystal Tear – Causes an explosion.

Liurnia of the Lakes: Minor Erdtree (Northwest) – Erdtree Avatar

• Magic-Shrouding Cracked Tear – Temporary boost to magic attacks.
• Lightning-Shrouding Cracked Tear – Temporary boost to lightning attacks.
• Holy-Shrouding Cracked Tear – Temporary boost to holy attacks.

Caelid: Minor Erdtree (West) – Erdtree Avatar

• Greenburst Crystal Tear – Boosts stamina recovery speed.
• Flame-Shrouding Crystal Tear – Temporary boost to fire attacks.

Caelid: Minor Erdtree (East) – Putrid Avatar

• Opaline Hardtear – Boosts all damage negation.
• Stonebarb Cracked Tear – Makes attacks more likely to break enemy stances.

Caelid: Overworld – This is along the road past Caelid Highway South. You should spot a Golden Seed sapling and near that is a pit. The Tear can be picked up from there.

• Windy Crystal Tear – Enhances dodge rolls.

Mount Gelmir: Minor Erdtree – Ulcerated Tree Spirit

• Leaden Hardtear – Temporarily boosts poise.
• Cerulean Hidden Tear – Eliminates all FP consumption.

Altus Plateau: Minor Erdtree – Wormface

• Crimsonspill Crystal Tear – Boosts max HP.
• Speckled Hardtear – Boosts resistance and heals status effects.

Altus Plateau: Second Church of Marika – Eleonora (hostile NPC invasion)

• Purifying Crystal Tear – Purifies the Lord of Blood’s curse. Might be useful when you’re fighting a secret boss named Mohg, Lord of Blood.

Leyndell: Overworld – This is west of the Minor Erdtree

• Winged Crystal Tear – Reduces equip load/encumbrance.

Leyndell: Minor Erdtree – Has a few mobs but no need to kill them

• Crimson Crystal Tear – Restores half of your total HP.
• Twiggy Cracked Tear – Briefly stops loss of runes on death.

Mountaintops of the Giants: Minor Erdtree – You do fight only one Erdtree Avatar here. However, it summons its buddy once it goes below 50% HP. The two will share the same health pool.

• Cerulean Crystal Tear – Restores half of your total FP.
• Crimson Bubbletear – Restores HP when near death.

Best Crystal Tear Combinations for the Flask of Wondrous Physick

The Flask of Wondrous Physick can be extremely helpful during Elden Ring’s challenging boss fights. Depending on what tears you insert into the flask, you can significantly increase your chances of surviving. There are a few crystal tear combinations for the Wondrous Physick that can really bring your character’s build to the next level.

Here are the best crystal tear combinations for the Flask of Wondrous Physick in Elden Ring:

Crimson Crystal Tear Opaline Bubbletear

The Crimson Crystal Tear combined with the Opaline Bubbletear can be a lifesaver when your HP is about to run out. Not only will the Crimson Crystal Tear replenish half your HP, but the Opaline Bubbletear will significantly negate damage from a devastating blow from a boss or enemy. In other words, this combination can save you from seeing those infamous “you died” words come across your screen.

Magic-Shrouding Cracked Tear Cerulean Hidden Tear

Combining the Magic-Shrouding Cracked Tear with the Cerulean Hidden Tear in the Wondrous Physick is incredibly smart for magic-based builds. These two tears will increase your magic’s overall damage output, while also removing FP consumption. Take a chug of these two tears right before using Comet Azur, and I promise you will obliterate any boss you’re up against.

Opaline Hardtear Strength-knot Crystal Tear

The perfect combination for strength builds, the Opaline Hardtear and the Strength-knot Crystal tear will turn you into an absolute monster. The former temporarily boosts all damage negation, while the latter temporarily boosts strength. This combination allows you to focus more on dealing damage to your enemies and less on dodging and healing.

Those are our picks for the best crystal tear combinations for the Flask of Wondrous Physick in Elden Ring. Remember, the number of combinations is endless considering there are so many crystal tears to be found in the game. Have fun mixing and matching and you may discover a unique combination that is perfect for Shadow of the Erdtree.